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Oct 5

Accelerometry-Derived Digital Biomarkers for Cardiometabolic Risk: A Population-Representative Tabular Benchmark with Uncertainty Quantification

Structured tabular data dominates clinical medicine, yet existing benchmarks fail to reflect real-world properties like complex survey sampling, demographic oversampling, and subgroup fairness. We introduce the NHANES Accelerometry Cardiometabolic Benchmark, derived from NHANES 2003-2006, comprising 1,381 adults with hip-worn accelerometry, fasting laboratory biomarkers, dietary intake, and anthropometrics. We evaluate three tabular learning methods -- ridge regression, XGBoost, and the foundation model TabPFN v2 -- to predict glycated haemoglobin (HbA1c), fasting triglycerides, and C-reactive protein (CRP) from activity phenotypes and lifestyle covariates. TabPFN v2 achieves the best overall performance (HbA1c R^2=0.156, CRP R^2=0.383), while triglycerides remain largely unpredictable (R^2 < 0.05), consistent with known genetic dominance. We apply split conformal prediction to generate distribution-free 90% prediction intervals and evaluate demographic coverage equity across sex and race/ethnicity subgroups. Marginal coverage aligns with the 90% target for CRP and HbA1c but falls below for triglycerides. At the subgroup level, we observe localized undercoverage (e.g., HbA1c for Mexican American participants), illustrating the gap between marginal guarantees and the conditional coverage required for clinical fairness. Code and data are at https://github.com/felizzi/nhanes-accel-cardiometabolic-benchmark.

  • 1 authors
·
Jun 28

Mitra-v2 Technical Report

We introduce Mitra-v2, a tabular foundation model that delivers state-of-the-art performance on real-world classification and regression problems, from credit-risk scoring and clinical prediction to equipment-failure detection and house-price estimation. Mitra-v2 is trained only on synthetic data, with a pretraining distribution that is much larger and more diverse than Mitra-v1's. Built on a small 2D Transformer backbone, Mitra-v2 supports longer contexts and larger feature spaces. Improved optimization lets it learn from this larger task distribution. We evaluate Mitra-v2 on the TabArena and TALENT benchmarks, comprising more than 300 real-world datasets under two evaluation protocols. On the full TabArena benchmark, Mitra-v2 delivers state-of-the-art performance at the level of the industry-scale TabFM and EXAONE Tabular models, while surpassing TabPFN-3 by a wide margin in both classification and regression. Mitra-v2 matches the 1.6B-parameter TabFM with only 5% of its size (77M parameters), delivering frontier performance at a fraction of the cost. On TALENT, Mitra-v2 remains among the leading models, clearly outperforming TabPFN-3 and TabICLv2. It also ranks first on classification tasks with more than ten classes, even though it was pretrained only on tasks with at most ten classes. These results make Mitra-v2 one of the strongest and most broadly applicable open tabular foundation models released to date. We release the model weights, the inference and fine-tuning code, and our evaluation results under the Apache-2.0 license.

  • 16 authors
·
Sep 2